Ketoconazole 2 percent shampoo is a broad-spectrum imidazole-dioxolane synthetic antifungal drug that alters the permeability of the cell membrane to prevent the in vitro development of the following common dermatophytes and yeasts: Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum; yeasts.